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Opposite sex Avatars?

Me and a friend were debating about this earlier hehe and we were wondering b/c we know Avatars are made from the DNA of the human driver and Na'vi DNA which is why they're similar to their driver in appearance, however do you think it is possible for a male driver to use a female avatar made from his DNA etc...and vice-a-versa.  My friend brought it up and I thought it was interesting...I mean if it still is a copy of your nervous system, and whatnot shouldn't it still work?  Like what if Jake's twin brother had actually been his twin sister would he still be able to drive it?  I know this is all hypothetical just trying to see what others think. 

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